Completed in 2013, the Age Related Eye Disease Study 2 (AREDS2) was a 5-year long study conducted by the National Eye Institute of the National Institutes of Health. This formula is based on the findings from this in-depth study of eye health and vision protection. PreserVision AREDS 2 Formula features the exact same levels of all six nutrients based on the latest clinical evidence from the AREDS 2 study. It includes all six clinically validated nutrients, and it builds on the original PreserVision AREDS Formula with lutein and zeaxanthin but replacing beta-carotene based on the updated findings.