Boldaloin^®  is traditionally applied as an agent stimulating secretion of bile and gastric juice and regulating frequency of defecation. The drug efficiency in the above mentioned indications is based exclusively on long period of application and experience. Traditionally used in case of indigestion accompanied by sensation of fullness in the abdomen, bile and gastric juice secretion disorders, mild spastic gastro-intestinal disorders. Traditionally applied for regulation of defecation frequency (mild constipation related to change of diet or residence place).

DIRECTIONS:

• As a cholepoietic preparation and to stimulate secretion of gastric juice: adults orally 1 tablet 3 times a day, children over 12 years of age and elderly individuals 1 to 2 tablets a day.
• As a mild agent regulating defecation: 1 to 3 tablets as a single dose, in the evening.
• Do not administer Boldaloin^® to children younger than 12 years of age.
• It is not recommended to use the drug for longer than 7 to 10 days without physician's consultation because of the possibility of weakening of intestinal vermiculation in case of long term use. 
• In case of cholelithiasis, apply the drug exclusively after consultation with a physician.
  
  

WARNINGS:

• Do not use the drug in case of hypersensitivity to any of the preparation components, liver cirrhosis, occlusion of bile ducts and alimentary tract, stenosis of alimentary tract, intestinal atonia (loss of normal smooth muscle tonus), appendicitis, inflammatory diseases of large intestine (e.g. Crohn's disease, ulcerative colon inflammation), stomach aches of unclear etiology, renal insufficiency, disorders of water-electrolyte balance.
• Observe special care while applying simultaneously with diuretic drugs.
• Avoid using during menstruation.
• It is not recommended to use during pregnancy and breast feeding. Possible application of the preparation is admissible only with a physician's approval.
• No adverse influence of Boldaloin^® on the ability to driver vehicles and operate moving mechanisms has been found.
• In large doses and in combination with diuretics, adrenocorticosteroids and licorice root, it may potentially cause hypokaliemia (decrease of potassium level). It is not recommended to apply Boldaloin^® simultaneously with anti-arrhythmic drugs and laxatives.
• In case of serious overdose, many times exceeding the recommended doses (taking of dozen or so tablets for several days), nausea, vomiting, diarrhea, electrolyte disorders, dehydration, cardiac rhythm disorders and increase of menstrual bleeding may occur. It is necessary to take orally about 10 g of activated carbon and consult a physician in case of overdose.
• In case of long application of high doses of aloe extract, albuminuria, hematuria and harmless accumulation of pigment in the intestinal mucosa (pseudomelanosis coli) occur, which usually disappears after withdrawal of the drug.
• Usually no undesired effects are observed. Sporadically possible vomiting, diarrhea, hypokaliemia (potassium level decrease), biliary colic and allergic reactions to the preparation components.
  Withdraw the drug in case of undesired symptoms. Change of urine color may appear in rare cases. In case of other undesired effects, not mentioned here, it is necessary to inform a physician.